Alkaloid Content

[DoomCat]

I remembered seeing this on CB's site a long time ago and thought i'd copy/paste it for people who may be interested. I cannot attest to how accurate this is and i am positive the profile varies highly depending on soil composition, type of leaf, way its dried and a lot of other variables but all the different alkaloids are fascinating:

Ajmalicine (Raubasine): Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer. Also found in Rauwolfia serpentina.

Akuammigine

Ciliaphylline: antitussive, analgesic. < 1% of total alkaloid content found in Kratom leaf.

Corynantheidine: μ -opioid antagonist, also found in Yohimbe. < 1% of total alkaloid content found in Kratom leaf.

Corynoxeine: Calcium channel blocker. < 1% of total alkaloid content found in Kratom leaf.

Corynoxine A and B: Dopamine mediating anti-locomotives. < 1% of total alkaloid content found in Kratom leaf.

Epicatechin: Antioxidant, antiaggregant, antibacterial, antidiabetic,
antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant,
antiviral, potential cancer preventative, alpha-amylase inhibitor. Also found in dark chocolate.

9-Hydroxycorynantheidine: Partial opioid agonist

7-hydroxymitragynine: Analgesic, antitussive, antidiarrheal; primary
psychoactive in Kratom, Roughly 2% of total alkaloid content found in Kratom leaf.

Isomitraphylline: Immunostimulant, anti-leukemic. < 1% of total alkaloid content found in Kratom leaf.

Isomitrafoline: < 1% of total alkaloid content found in Kratom leaf.

Isopteropodine: Immunostimulant

Isorhynchophylline: Immunostimulant. < 1% of total alkaloid content found in Kratom leaf.

Isospeciofoline: < 1% of total alkaloid content found in Kratom leaf.

Mitraciliatine: < 1% of total alkaloid content found in Kratom leaf.

Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial,
possible psychedelic (5-HT2A) antagonist. Roughly 66% of total alkaloid content found in Kratom leaf.

Mitragynine oxindole B. < 1% of total alkaloid content found in Kratom leaf.

Mitrafoline: < 1% of total alkaloid content found in Kratom leaf.

Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. <1% of total alkaloid contents in Kratom leaf.

Mitraversine

Paynantheine: Indole alkaloid. Smooth muscle relaxer. 8.6% to 9% of total alkaloid contents in Kratom leaf.

Rhynchophylline: Vasodilator, antihypertensive, calcium channel blocker,
antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic. < 1% of total alkaloid content found in Kratom leaf.

Speciociliatine: Weak opioid agonist. 0.8% to 1% of total alkaloid content of Kratom leaf, unique to Kratom.

Speciofoline

Speciogynine: Smooth muscle relaxer. 6.6% to 7% of total alkaloid contents of Kratom leaf.

Speciophylline: Indole alkaloid. Anti-leukemic. <1% of total alkaloid contents of Kratom leaf.

Stipulatine

Tetrahydroalstonine: Hypoglycemic, anti-adrenergic (at alpha-2)

[heme2016]

Corynoxine A and B: Dopamine mediating anti-locomotives

Damn. Does this mean I can't ride Amtrak after taking kratom?

[herbalhippie]

omg

[DoomCat]

Corynoxine A and B: Dopamine mediating anti-locomotives

Damn. Does this mean I can't ride Amtrak after taking kratom?

bhahahahahahahhahahaa.....tooo funny!

[BallzDeep9]

but all the different alkaloids are fascinating:

Amazing... Good Info - thanks for posting!

I think this explains why they can't easily 1- Synthesize or 2- Patent the plant.. It's much, much, more than just Mitragyna !!

[Worldfairgirl]

Thank you! This is indeed interesting and helpful!

[mivanqua]

but all the different alkaloids are fascinating:

Amazing... Good Info - thanks for posting!

I think this explains why they can't easily 1- Synthesize or 2- Patent the plant.. It's much, much, more than just Mitragyna !!

Also why extracts lack a major part of the experience (sans full spectrum, that is.) Mit and 7ohm are the intoxicating alkaloids, but there's WAY more to the kratom experience than these two.

[DirtyRadish]

Thank you for posting this, absolutely extraordinary!