Alkaloid Content
Posted: Mon Apr 16, 2018 6:21 pm
I remembered seeing this on CB's site a long time ago and thought i'd copy/paste it for people who may be interested. I cannot attest to how accurate this is and i am positive the profile varies highly depending on soil composition, type of leaf, way its dried and a lot of other variables but all the different alkaloids are fascinating:
Ajmalicine (Raubasine): Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer. Also found in Rauwolfia serpentina.
Akuammigine
Ciliaphylline: antitussive, analgesic. < 1% of total alkaloid content found in Kratom leaf.
Corynantheidine: μ -opioid antagonist, also found in Yohimbe. < 1% of total alkaloid content found in Kratom leaf.
Corynoxeine: Calcium channel blocker. < 1% of total alkaloid content found in Kratom leaf.
Corynoxine A and B: Dopamine mediating anti-locomotives. < 1% of total alkaloid content found in Kratom leaf.
Epicatechin: Antioxidant, antiaggregant, antibacterial, antidiabetic,
antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant,
antiviral, potential cancer preventative, alpha-amylase inhibitor. Also found in dark chocolate.
9-Hydroxycorynantheidine: Partial opioid agonist
7-hydroxymitragynine: Analgesic, antitussive, antidiarrheal; primary
psychoactive in Kratom, Roughly 2% of total alkaloid content found in Kratom leaf.
Isomitraphylline: Immunostimulant, anti-leukemic. < 1% of total alkaloid content found in Kratom leaf.
Isomitrafoline: < 1% of total alkaloid content found in Kratom leaf.
Isopteropodine: Immunostimulant
Isorhynchophylline: Immunostimulant. < 1% of total alkaloid content found in Kratom leaf.
Isospeciofoline: < 1% of total alkaloid content found in Kratom leaf.
Mitraciliatine: < 1% of total alkaloid content found in Kratom leaf.
Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial,
possible psychedelic (5-HT2A) antagonist. Roughly 66% of total alkaloid content found in Kratom leaf.
Mitragynine oxindole B. < 1% of total alkaloid content found in Kratom leaf.
Mitrafoline: < 1% of total alkaloid content found in Kratom leaf.
Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. <1% of total alkaloid contents in Kratom leaf.
Mitraversine
Paynantheine: Indole alkaloid. Smooth muscle relaxer. 8.6% to 9% of total alkaloid contents in Kratom leaf.
Rhynchophylline: Vasodilator, antihypertensive, calcium channel blocker,
antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic. < 1% of total alkaloid content found in Kratom leaf.
Speciociliatine: Weak opioid agonist. 0.8% to 1% of total alkaloid content of Kratom leaf, unique to Kratom.
Speciofoline
Speciogynine: Smooth muscle relaxer. 6.6% to 7% of total alkaloid contents of Kratom leaf.
Speciophylline: Indole alkaloid. Anti-leukemic. <1% of total alkaloid contents of Kratom leaf.
Stipulatine
Tetrahydroalstonine: Hypoglycemic, anti-adrenergic (at alpha-2)
Ajmalicine (Raubasine): Cerebrocirculant, antiaggregant, anti-adrenergic (at alpha-1), sedative, anticonvulsant, smooth muscle relaxer. Also found in Rauwolfia serpentina.
Akuammigine
Ciliaphylline: antitussive, analgesic. < 1% of total alkaloid content found in Kratom leaf.
Corynantheidine: μ -opioid antagonist, also found in Yohimbe. < 1% of total alkaloid content found in Kratom leaf.
Corynoxeine: Calcium channel blocker. < 1% of total alkaloid content found in Kratom leaf.
Corynoxine A and B: Dopamine mediating anti-locomotives. < 1% of total alkaloid content found in Kratom leaf.
Epicatechin: Antioxidant, antiaggregant, antibacterial, antidiabetic,
antihepatitic, anti-inflammatory, anti-leukemic, antimutagenic, antiperoxidant,
antiviral, potential cancer preventative, alpha-amylase inhibitor. Also found in dark chocolate.
9-Hydroxycorynantheidine: Partial opioid agonist
7-hydroxymitragynine: Analgesic, antitussive, antidiarrheal; primary
psychoactive in Kratom, Roughly 2% of total alkaloid content found in Kratom leaf.
Isomitraphylline: Immunostimulant, anti-leukemic. < 1% of total alkaloid content found in Kratom leaf.
Isomitrafoline: < 1% of total alkaloid content found in Kratom leaf.
Isopteropodine: Immunostimulant
Isorhynchophylline: Immunostimulant. < 1% of total alkaloid content found in Kratom leaf.
Isospeciofoline: < 1% of total alkaloid content found in Kratom leaf.
Mitraciliatine: < 1% of total alkaloid content found in Kratom leaf.
Mitragynine: Indole alkaloid. Analgesic, antitussive, antidiarrheal, adrenergic, antimalarial,
possible psychedelic (5-HT2A) antagonist. Roughly 66% of total alkaloid content found in Kratom leaf.
Mitragynine oxindole B. < 1% of total alkaloid content found in Kratom leaf.
Mitrafoline: < 1% of total alkaloid content found in Kratom leaf.
Mitraphylline: Oxindole alkaloid. Vasodilator, antihypertensive, muscle relaxer, diuretic, antiamnesic, anti-leukemic, possible immunostimulant. <1% of total alkaloid contents in Kratom leaf.
Mitraversine
Paynantheine: Indole alkaloid. Smooth muscle relaxer. 8.6% to 9% of total alkaloid contents in Kratom leaf.
Rhynchophylline: Vasodilator, antihypertensive, calcium channel blocker,
antiaggregant, anti-inflammatory, antipyretic, anti-arrhythmic, antithelmintic. < 1% of total alkaloid content found in Kratom leaf.
Speciociliatine: Weak opioid agonist. 0.8% to 1% of total alkaloid content of Kratom leaf, unique to Kratom.
Speciofoline
Speciogynine: Smooth muscle relaxer. 6.6% to 7% of total alkaloid contents of Kratom leaf.
Speciophylline: Indole alkaloid. Anti-leukemic. <1% of total alkaloid contents of Kratom leaf.
Stipulatine
Tetrahydroalstonine: Hypoglycemic, anti-adrenergic (at alpha-2)
