Kràtom and prescription drug interactions

[boureka]

I'm not a knowledgeable person on this topic. Furthermore, I don't think many physicians are either. But it seems like an important discussion to have. Which drugs might interfere with our kratom and which drugs might adversely be affected by it. Which prescriptions+ kràtom= a bad scenario. I tried to do a deep dive and only found some conflicting info on certain psychiatric meds. Nothing on anything else. Anyone?

[Kelleytoons]

While I'm not sure of any studies (there are VERY few actual studies conduction on kratom) the general wisdom is that opioids and kratom use is NOT recommended. You can definitely take them the same day, just not at the same time (I have done this from time to time - taken some script opioids in the morning, for example, and five or six hours later taken some kratom, and no ill effects are noticed. Indeed, it doesn't even seem to make the kratom more or less intense - just like any other kratom dose).

The problem is that without studies all we have are what apocryphal things we have heard or come up with. I take three prescription drugs regularly and I don't even give it a thought as to my kratom use.

[boureka]

Our youngest takes Xanax, Adderall, and Fluvoxamine (hope I got that right) which is an SSRI that specifically targets OCD. Doses on kratom 3 times/day. Hate all that Rx stuff going into his system, but that's besides the point. So, I'm a mom. I worry. It's not the occasional dentist prescribed Percocet that concerns me but the long term cross reactions. Especially with the SSRIs. There's no way to ask his doctor.

[OriginalLHB]

It is impossible to know the full medicinal value of kratom if it is constantly competing with other pharmaceuticals. I am amazed at the extent to which kratom serves as an incredibly effective substitute for benzos, opioids and anti depressants. While I have been on kratom I have been able to quit all of these things, and feel better mentally than I have felt in decades. I would not have known, nor believed it, if I was still on those meds.

[IdiopathicPain247]

I'm not a knowledgeable person on this topic. Furthermore, I don't think many physicians are either. But it seems like an important discussion to have. Which drugs might interfere with our kratom and which drugs might adversely be affected by it. Which prescriptions+ kràtom= a bad scenario. I tried to do a deep dive and only found some conflicting info on certain psychiatric meds. Nothing on anything else. Anyone?

I take Citalopram 40mg, and Clonazepam 1.5mg . I found this page at kratom.org that says Kratom interacts with a BUNCH of meds.
Kratom & Angiotensin II Receptor Blockers
Kratom & Antibiotics
Kratom & Anti-Emetics
Kratom & Antihistamines
Kratom & Antipsychotics
Kratom & Alcohol
Kratom & Barbiturates
Kratom & Beta-Blockers
Kratom & Benzodiazepines
Kratom & Blood Thinners
Kratom & Biguanides
Kratom & Calcium Channel Blockers
Kratom & Central Agonists
Kratom & Diuretics
Kratom & Dipeptidyl Peptidase-4 (DPP-4) Inhibitors
Kratom & GLP-1 Receptor Agonists
Kratom & Immunosuppressants
Kratom & Insulin
Kratom & MAO Inhibitors
Kratom & Meglitinides
Kratom & NDRI Medications
Kratom & NSAID Painkillers
Kratom & Opiate Painkillers
Kratom & PDE5 Inhibitors
Kratom & Peripheral Adrenergic Inhibitors
Kratom & Proton Pump Inhibitors
Kratom & SARI Medications
Kratom & SDA Medications
Kratom & SNRI Medications
Kratom & SSRI Medications
Kratom & SGLT-2 Inhibitors
Kratom & Statin Drugs
Kratom & Stimulants
Kratom & Tricyclic Antidepressants
Kratom & Z-Drugs
Kratom & 5-Alpha-Reductase Inhibitors (5-ARIs)
Bottom Line: Can I Take Kratom With My Medications

Is Kratom Safe to Take With Other Medications?
Kratom itself isn’t particularly dangerous. However, it isn’t considered safe to take kratom with most prescription medications.

Certain classes of medications are especially dangerous — such as opiate painkillers, barbiturates, benzodiazepines, antipsychotics, blood pressure medications, and any compounds metabolized by the CYP2D6 enzymes (there are a lot).

Kratom has a powerful array of health benefits that largely rely on its ability to shift the neurochemical balance of the brain. If taken with other medications that cause a similar shift, it could increase the risk of side effects.

In general, if you’re taking any kind of prescription medication you should speak with your doctor about kratom first.

https://kratom.org/interactions/

[boureka]

@ idiopathic
You can't speak to a lot ofdoctors because all too often they know nothing about kratom and a wiki search will just provide...a reefer madness attitude frequently.
What I was hoping was, in the absence of really any research, to hear people's stories. Like kelleytoons. Or someone who's longterm on Rx's like my son's.
But wow..that link was a little over the top I'm thinking? It seems like you could only take kràtom with bread and water. (And not even that because you want to have an empty stomach.)

[SeventhHeaven]

...
Is Kratom Safe to Take With Other Medications?
Kratom itself isn’t particularly dangerous. However, it isn’t considered safe to take kratom with most prescription medications.

Certain classes of medications are especially dangerous — such as opiate painkillers, barbiturates, benzodiazepines, antipsychotics, blood pressure medications, and any compounds metabolized by the CYP2D6 enzymes (there are a lot).

Kratom has a powerful array of health benefits that largely rely on its ability to shift the neurochemical balance of the brain. If taken with other medications that cause a similar shift, it could increase the risk of side effects.
...
https://kratom.org/interactions/

Yep, and you beat me to it - https://kratom.org/interactions/ has a HUGE amount of info about kratom and Rx drug interactions, including a good-sized table with the level of danger with many different classes of drugs.

boureka, that's where the table comes in - it's color-coded (green/yellow/red) and with numbers within the colors showing the level of potential dangerous interactions.

[boureka]

You know when you open up this link on your phone, you don't see the color coded part unless you scroll sideways so thanks.

[IdiopathicPain247]

@ idiopathic
You can't speak to a lot ofdoctors because all too often they know nothing about kratom and a wiki search will just provide...a reefer madness attitude frequently.
What I was hoping was, in the absence of really any research, to hear people's stories. Like kelleytoons. Or someone who's longterm on Rx's like my son's.
But wow..that link was a little over the top I'm thinking? It seems like you could only take kràtom with bread and water. (And not even that because you want to have an empty stomach.)

The list shocked me!! Bread and water is about the only thing you can take. So far THOUGH, I am taking Citalopram, Clonazepam, Gabapentin, some Tramadol occasionally, an NSAID, and occasionally Benadryl. I have had no problems with taking 10mg's of Kratom at this point. kratom.org is a friendly towards Kratom use. I think the org was putting out the best information/warnings so that Kratom users will be careful. I am sure some interactions can be worse depending on what is being treated and the amount one is taking. I am on 40mg's of the SSRI. It would seem like there would be some problems with taking Kratom also, but there is none.

[boureka]

@ idiopathic
THAT'S what I wanna hear! As I said, anecdotal is all we have at this point. But enough anecdotal and you have the basis for a hypothesis and some research.