Low Dose Naltrexone / All Day Chemist

[BallzDeep9]

OK let's kick off a Discussion on LDN, or more likely ULDN = Ultra Low Dose Naltrexone. What is this, Why do you need it, Where to get it?

PART 1: I'm no expert on ULDN, I've not tried it yet... ULDN has become a fairly popular treatment for opioid tolerance. Proven to up regulate opioid receptors and When used with Caution! . Can restore your kratom tolerance to almost "virgin levels" - Especially important, for those who use kratom for chronic pain. There is a TON of information, online... Major website LINK / 2 or 3 large Facebook groups/ Lots of stuff on Reddit, in r/kratom sub and opiate subs.

Naltrexone is Legal, a prescription drug available everywhere (including Canadian pharmacy with NO prescription!). It's NOT a controlled substance. Cost is like.. pennies per dose!

https://www.reddit.com/r/kratom/search? ... ance&t=all

https://sites.google.com/site/dudleyslo ... obtain-ldn

PART 2: All Day Chemist - IS a well known, Offshore Pharmacy that sells many legal drugs, including Naltrexone. ADC does not sell ANY controlled medications - Don't bother looking for Benzo's or any dope there. So.. I'm posting about ADC, because #1 yes I have ordered there, many years ago.. That's how I know, they have been in business for like 20 years. That's a hella long time on the Internet!! https://www.alldaychemist.com/

ADC does a Big Business in boner pills! Yes and, now both Viagra and Cialis are generic, prices are really cheap here.. what else? Pretty much any medication you can think of.. Some stuff that's expensive in the USA - cholesterol lowering drugs, Lipitor? I dunno. Literally 100's of popular meds, very cheap AND manufactured by leading Indian pharma companies - The same ones that make generics for USA. India is a world leader in drug manufacturing.

https://www.alldaychemist.com/aboutus

So... that's my Information! I'm considering an order from ADC. Is anyone interested in ULDN ? We could have a private Group? I guess, might be fun to compare notes. As I posted in the tolerance thread.. I did ask my Doctor this week about it. Personally, I'm not sure I even NEED it? my kratom Grams Per Day is pretty low - But I know for sure, lots of folks are having issues / either over doing the leaf / or needing pain relief and taking way, way, too much & dealing with the Tolerance Bug.

[conscious_conundrum]

I am very interested in the ULDN...… I might have to place an order after some more research

[BurntEnds]

There's quite a number of research papers looking at appropriate dosing and what exactly is happening at the receptor level. I've done a fair amount of reading and self experimentation on the subject. I need to find a couple of the more in depth papers I found on NCBI regarding why ULDN is so effective but I can't find them at the moment with a quick cursory search.

Here's a link to a basic overview of one study published by science direct:

https://www.sciencedirect.com/science/a ... 9397001972

[FartBlaster]

Thanks for posting this. My question is all day chemist sells 50mg pills so how would you cut that? Like low dose is .5-5mg right?

[CatfatherB]

Thanks for posting this. My question is all day chemist sells 50mg pills so how would you cut that? Like low dose is .5-5mg right?

That's what I'd like to know, I think fairly recently a guy on r/kratom said he gave his wife a whole naltrexone and sent her straight to withdrawls, I think she was on more than kratom but he said she was inconsolable.

[BurntEnds]

Thanks for posting this. My question is all day chemist sells 50mg pills so how would you cut that? Like low dose is .5-5mg right?

Much much lower doses than 0.5-5mg, that would be considered in the range of LDN or Low Dose Naltrexone. There's also ULDN Ultra Low Dose Naltrexone which is what this thread was started about which is in the range of 1-10 micro grams, about 500-1000 times smaller than LDN. There's another range which is even smaller which I can't remember or find the nomenclature for at the moment which is in the nanogram or even picogram range so another 1000-1,000,000 times smaller. There's research been done on all of them which can be found by doing a Google search and looking for clinical studies and research papers.

As far as dosing it needs to be done using volumetric dilution because you're dealing with such small amounts that there's no way to accurately split off any amount of a tablet without a dilution process.. Rather than trying to explain I believe there's a Reddit thread that you can find with a basic search that goes into details. Alternatively if you can find a product that has already been diluted by a compounding pharmacy that would be the easiest way to go and not require any "sciencing calculations" on your part lol

[BallzDeep9]

Much much lower doses than 0.5- 5mg, that would be considered in the range of LDN or Low Dose Naltrexone. There's also ULDN Ultra Low Dose Naltrexone ... in the range of 1-10 micro grams,

right so, LDN starts at 0.5 mg which is = 500 mcg. ULDN starts, around 5 mcg ? Advice is to start low, take it slow.. I read about ppl moving up to, anywhere from ultra low 10, to around 100 mcg - again that's micrograms

As far as dosing it needs to be done using volumetric dilution because you're dealing with such small amounts that there's no way to accurately split off any amount of a tablet without a dilution process.... Alternatively (use a) compounding pharmacy that would be the easiest way to go ...

absolutely, my understanding is a usual dose from Compounding Pharmacy, 1.5 mg which = 1500 mcg and would be easy to work with.. convert to liquid, distilled water using a measuring cylinder Amazon

The standard Naltrexone 50 mg tablet from ADC, 1 tablet would last forever.. you'd need to convert 1 tab to 50 ml, then keep only 10 ml, liquid in the fridge?

[BurntEnds]

You are correct Ballz however I've found for me personally much over 1mcg at a time results in a fair amount of generalized discomfort, restlessness, and potentially some.... Uhh let's just say running to the bathroom rather suddenly within an hour or so That improves over time with repeated dosing but I've found far lower doses to still be very effective with less of the unpleasant side effects

Some of the more recent research I've found shows that doses even as low as in the several hundred picogram range have notable effects depending on what the desired outcome is that you're after.

The article I posted a link to higher up in this thread talks about testing doses from 1 nanogram/kg-100ng/kg and finding the greatest efficacy for increasing the nociceptive effects of morphine at a dose of 10ng/kg in mice. After conversion over to appropriate human dosing, which factors in the metabolic differences, that works out to about .81ng per kg for a human equivalent dose (HED). This means for me, as I am close to 100kg, it would be a dose of approximately 81ng if I were going for greater pain relief. This is about 1/12th the lowest recommended starting range of 1mcg for ULDN. As we know with Kratom sometimes less is more and I think this is another instance where I've found that to be true for me.

There's actually quite a number of research articles published in scientific journals and on NCBI looking a surprising variety of potential uses and effects that use an insanely wide range of dosing all the way from picograms to mg depending on what they are looking at. These articles are where I've found some of the most useful information beyond the forum posts on Reddit. I find it to be a fascinating subject and appreciate you starting this thread

[Thekid1420]

I have been scrolling through all day chemist and am interested in some of the boner pills. I believe generic Viagra is Sildenafil and generic Cialis is Tadalafil, right??
Has anyone ever ordered these from them? Curious which listing I should go with. I've never ordered from this place but if Ballz n others vouch for them then I feel pretty comfortable in spending some money. Any advice would be appreciated. Thanks in advance.

[Lambeezy]

Burnt ends it seems like you are speaking from experience.. so what have your results been?

[labdog03]

I have really wanted to try this, but I never could get past the supplier requiring a prescription?

[BallzDeep9]

generic Cialis is Tadalafil, right ?? Has anyone ever ordered these from them?

yes, and yes. I did order the Manly pills from ADC.. like 15 years ago lol . Which just goes to prove, they've been in business a long long time & thats why I posted this.. Its a legit resource. You can also search on Reddit, on various forums like bodybuilding, etc ADC has been well known for years.

There's still an issue of sending $ overseas. Some ppl have used a temp CC like a green dot card U load at Walmart? Like I say its been many years for me, anyone who orders from ADC would need to figure out the payments. Not unlike kratom which has sketchy payments too lol

Cialis = tadalafil which, besides ED, is also FDA approved for treatment of enlarged prostate. Ever have a problem urinating due to prostate? Try tadalafil at low doses. I think they even make 2.5 mg pills the lowest. I would buy the 20 mg (and divide into 10 low doses). IMO tadalafil aka the weekend pill, is superior to sildenafil "viagra".. India pharma manufactures like Ajanta, Cipla, are world class. You can buy these products: Tadacip, Tadalis, from ADC they are sold otc in other countries

ADC also sells: Gabapentin, which is anti seizure and is used to control RLS, a known side effect of kratom withdrawal.. Personaly I am interested in ULDN, but reducing those 50 mg Naltrexone pills would be a real hassle, you'd need to be very careful as Burnt has pointed out

ADC also carries Memantine, another NMDA antagonist, tolerance buster we could look into.. Check this out: Reducing Opiate Tolerance with Memantine - https://www.khemcorp.com/reducing-opiat ... tolerance/